Journal: Chemical reviews
Article Title: Natural Products as Platforms To Overcome Antibiotic Resistance
doi: 10.1021/acs.chemrev.7b00283
Figure Lengend Snippet: MIC Assays of Analogs a
Article Snippet: Given the enhanced activity against D-Ala-D-Lac-producing strains, Boger’s hypothesis regarding a single atom mutation restoring a critical hydrogen bond is clearly a valid one ( ). table ft1 table-wrap mode="anchored" t5 caption a7 S. aureus E. faecalis E. faecium E. faecalis ATCC 25923 ATCC 43300 BM 4166 ATCC BAA-2317 ATCC 51299 QC MRSA VanA VanA VanB Vancomycin (4) 0.5 0.5 250 250 8 287 Y=S >32 >32 >32 >32 >32 288 Y=NH nd nd 0.5 0.5 nd 289 Y=H 2 nd nd 31 31 nd 291 Y=O CBP 0.03 0.03 2.5 2.5 0.03 292 Y=S CBP 2 2 4 4 2 293 Y=NH CBP 0.03 0.06 0.005 0.005 0.06 294 Y=H 2 CBP 0.5 0.25 0.13 0.06 0.5 295 Y=O CBP C0 nd nd 5 5 nd 296 Y=O CBP C1 nd nd 0.25 0.5 nd 297 Y=O CBP C5 nd nd 2 2 nd 298 Y=H 2 CBP C1 nd nd 0.01 0.005 nd Open in a separate window Open in a separate window a Color code indicates approximate x -fold change in activity relative to vancomycin.
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